Heme Oxygenase-1 Promoter Polymorphism Protects Liver Allograft
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چکیده
منابع مشابه
Heme oxygenase-1 protects the heart.
The seminal discovery of nitric oxide (NO) in the 1980s unraveled the novel concept that an endogenous production of a gaseous substance such as NO can impart diverse and critical functional effects on a wide spectrum of biological and pathological processes. Intense investigations in the chemistry and biology of NO have led to numerous fruitful discoveries, enhancing our understanding of many ...
متن کاملHeme oxygenase-1 gene promoter microsatellite polymorphism is associated with progressive atherosclerosis and incident cardiovascular disease.
OBJECTIVE The enzyme heme oxygenase-1 (HO-1) exerts cytoprotective effects in response to various cellular stressors. A variable number tandem repeat polymorphism in the HO-1 gene promoter region has previously been linked to cardiovascular disease. We examined this association prospectively in the general population. APPROACH AND RESULTS Incidence of stroke, myocardial infarction, or vascula...
متن کاملMicrosatellite polymorphism in the heme oxygenase-1 promoter is associated with nonsevere and late-onset preeclampsia.
Preeclampsia is a serious and phenotypically heterogeneous vascular pregnancy disorder. Heme oxygenase-1 (HO-1) is a stress response enzyme that may protect the maternal endothelium and facilitate adequate metabolic adaptation to pregnancy by its antioxidant and anti-inflammatory functions. HO-1 stress response is modulated by HO-1 gene (HMOX1) polymorphisms. Individuals with the long allele of...
متن کاملHeme oxygenase-1 gene promoter polymorphism and decline in lung function in Japanese men.
Content/gold/GOLD_USAPackageInsert.pdf. 4 Shingadia D, Novelli V. Diagnosis and treatment of tuberculosis in children. Lancet Infect Dis 2003;3:624–32. 5 ATS/CDC. Targeted tuberculin testing and treatment of latent tuberculosis infection. Joint Statement of the American Thoracic Society (ATS) and the Centers for Disease Control and Prevention (CDC). Am J Respir Crit Care Med 2000;161:S221–47. 6...
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INTRODUCTION: Heme oxygenase-1 (HO-1) is a stress response enzyme, which catalyses the breakdown of heme into biliverdin-IX alpha, carbon monoxide and ferrous iron. Under situations of oxidative stress, heat stress, ischemia/reperfusion injury or endotoxemia, HO-1 has been shown to be induced and to elicit a protective effect. The mechanism of how this protective effect is executed is unknown. ...
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ژورنال
عنوان ژورنال: Indian Journal of Surgery
سال: 2015
ISSN: 0972-2068,0973-9793
DOI: 10.1007/s12262-015-1309-5